ABSTRACT

The aim of our study was to characterize the group of patients suffering from dermatitis herpetiformis Duhring (DH) and to make the statistical analysis of monitored parameters. We retrospectively analysed the data of 122 patients with DH (age, gender, the severity of DH, tissue transglutaminase antibodies IgA (IgA-TGA) level and dapsone dose). The mild form of DH was recorded in 69 patients (56.6%), the moderate form in 48 patients (39.3%) and the severe form in 5 patients (4.1%); 118 patients (96.7%) are on dapsone therapy, 3.2% of patients are only on gluten-free diet. The median of average IgA-TGA in the mild form is 6.25 U/ml, in the moderate form 14.45 U/ml and in the severe form 10.33 U/ml. Although the significant relation of the IgA-TGA to the disease severity was not confirmed, there is some trend in the increase of the IgA-TGA level from mild to moderate and severe form of DH.

摘要

我们研究的目的是表征患有疱疹样杜林皮炎 (DH) 的患者组，并对监测参数进行统计分析。我们回顾性分析了122例DH患者的数据（年龄、性别、DH严重程度、组织转谷氨酰胺酶抗体IgA（IgA-TGA）水平和氨苯砜剂量）。DH 轻度型 69 例（56.6%），中度型 48 例（39.3%），重度型 5 例（4.1%）；118 名患者 (96.7%) 接受氨苯砜治疗，3.2% 的患者仅接受无麸质饮食。轻度形式的平均 IgA-TGA 的中位数为 6.25 U/ml，中度形式为 14.45 U/ml，重度形式为 10.33 U/ml。尽管尚未证实 IgA-TGA 与疾病严重程度的显着关系，