The objective of the study was to examine the association between fatigue (measured by the Multidimensional Fatigue Inventory; MFI-20) and physical activity (measured by the Saltin-Grimby Physical Activity Level Scale; SGPALS) in a large cohort of patients (≥18 years) with myasthenia gravis (MG) including relevant disease - and lifestyle-related factors. A total of 1463 persons, registered at the Danish National Registry of Patients with a MG diagnosis, according to the International Classification of Diseases, received a web-based survey. A total of 779 patients (53% women, mean [SD] age 60.8 [15.5]) responded. The remaining persons were either non-responders (n = 390) or could not confirm the MG diagnosis (n = 294). The most prominent MFI-20 fatigue domains were general fatigue (median [inter-quartile ranges, IQR], 13 [10–16]) and physical fatigue (median [IQR], 13 [9–15]), and 386 (53%) patients reported low levels of physical activity. All fatigue domains were associated with physical activity (p<.01). Higher level of physical activity was associated with lower levels of fatigue. Important factors for the association were myasthenia gravis disease severity (measured by the Myasthenia Gravis Activities of Daily Living profile), body mass index, insomnia (measured by the Insomnia Severity Index) job-status, comorbidity, and cohabitation.

该研究的目的是在一大群患者（≥18年）重症肌无力 (MG) 包括相关疾病和生活方式相关因素。根据国际疾病分类，共有 1463 名在丹麦国家诊断患者登记处登记的 MG 患者接受了一项基于网络的调查。共有 779 名患者（53% 为女性，平均 [SD] 年龄 60.8 [15.5]）做出反应。其余人要么是无反应者（n  = 390），要么无法确认 MG 诊断（n = 294）。最突出的 MFI-20 疲劳域是一般疲劳（中位数 [四分位数间距，IQR]，13 [10-16]）和身体疲劳（中位数 [IQR]，13 [9-15]）和 386 (53 %) 患者报告的体力活动水平较低。所有疲劳域都与体力活动相关 ( p <.01)。较高的身体活动水平与较低的疲劳水平有关。该关联的重要因素是重症肌无力疾病严重程度（由重症肌无力日常生活活动概况衡量）、体重指数、失眠（由失眠严重程度指数衡量）工作状态、合并症和同居。