Regulatory T cells (Tregs) are widely recognised as a subset of CD4⁺CD25⁺FOXP3⁺ T cells that have a key role in maintaining immune homeostasis. The impact of HIV-1 infection on immunological properties and effector functions of Tregs has remained the topic of debate and controversy. In the present study, we investigated transcriptional profile and functional properties of Tregs in HIV-1-infected individuals either receiving antiretroviral therapy (ART, n = 50) or long-term non-progressors (LTNPs, n = 24) compared to healthy controls (HCs, n = 38).

中文翻译：

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HIV感染个体中抗逆转录病毒疗法和长期非进展者的调节性T细胞的差异转录和功能特性

调节性T细胞（Tregs）被广泛认为是CD4 ⁺ CD25 ⁺ FOXP3 ⁺ T细胞的子集，在维持免疫稳态方面具有关键作用。HIV-1感染对Tregs的免疫学性质和效应子功能的影响一直是争论和争议的话题。在本研究中，我们调查了 与健康对照组相比，接受抗逆转录病毒疗法（ART，n  = 50）或长期非进展（LTNP，n = 24）的HIV-1感染者中Tregs的转录特征和功能特性。（HC，n  ＝ 38）。