Progressive deterioration of the central nervous system (CNS) is commonly associated with aging. An important component of the neurovasculature is the blood–brain barrier (BBB), majorly made up of endothelial cells joined together by intercellular junctions. The relationship between senescence and changes in the BBB has not yet been thoroughly explored. Moreover, the lack of in vitro models for the study of the mechanisms involved in those changes impede further and more in-depth investigations in the field. For this reason, we herein present an in vitro model of the senescent BBB and an initial attempt to identify senescence-associated alterations within.

中枢神经系统 (CNS) 的进行性恶化通常与衰老有关。神经脉管系统的一个重要组成部分是血脑屏障 (BBB)，主要由通过细胞间连接连接在一起的内皮细胞组成。衰老与 BBB 变化之间的关系尚未得到彻底探索。此外，缺乏用于研究这些变化所涉及的机制的体外模型阻碍了该领域进一步和更深入的研究。出于这个原因，我们在此提出了一个衰老 BBB 的体外模型，并初步尝试识别其中与衰老相关的变化。