ABSTRACT

HCMV-encoded microRNAs (hcmv-miRNAs) are non-coding and non-immunogenic molecules that target numerous cellular genes and allow the virus to modulate the host’s signalling pathways, thus favouring viral survival and replication. Given their capacity to silence the human genes involved in various physiological processes, these hcmv-miRNAs have now emerged as a potential clinical biomarker in many human diseases. In this review, we summarize the evidence published on the diagnostic and prognostic value of hcmv-miRNAs in several human diseases and their clinical implications. Specifically, we discuss the role of hcmv-miRNAs in the development of cardiovascular diseases and cancer by silencing tumour suppressors. We also examine the current knowledge on the utility of some hcmv-miRNAs in predicting HCMV viraemia recurrence in transplant patients, as well as the interference of hcmv-miRNAs in the development of an appropriate immune response against other viral infections, which might have therapeutic implications.

Abbreviations: HCMV, human cytomegalovirus; hcmv-miRNA, HCMV-encoded microRNAs

摘要

HCMV 编码的 microRNA (hcmv-miRNA) 是非编码和非免疫原性分子，可靶向许多细胞基因并允许病毒调节宿主的信号通路，从而有利于病毒的存活和复制。鉴于它们能够沉默参与各种生理过程的人类基因，这些 hcmv-miRNA 现在已成为许多人类疾病的潜在临床生物标志物。在这篇综述中，我们总结了已发表的关于 hcmv-miRNA 在几种人类疾病中的诊断和预后价值及其临床意义的证据。具体来说，我们通过沉默肿瘤抑制因子来讨论 hcmv-miRNA 在心血管疾病和癌症发展中的作用。我们还研究了一些 hcmv-miRNA 在预测移植患者 HCMV 病毒血症复发方面的效用的当前知识，

缩写： HCMV，人巨细胞病毒；hcmv-miRNA，HCMV 编码的 microRNA