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Ambient ionization mass spectrometry applied to new psychoactive substance analysis
Mass Spectrometry Reviews ( IF 6.6 ) Pub Date : 2021-05-26 , DOI: 10.1002/mas.21695
Maria Del Mar Boronat Ena 1 , David A Cowan 1 , Vincenzo Abbate 1
Affiliation  

In the past decade a plethora of drugs with similar effects to controlled psychoactive drugs, like cannabis, amfetamine (amphetamine), or lysergic acid diethylamide, have been synthesized. These drugs can collectively be classified under the term new psychoactive substances (NPS) and are used for recreational purposes. The novelty of the substances, alongside the rapid rate of emergence and structural variability, makes their detection as well as their legal control highly challenging, increasing the demand for rapid and easy-to-use analytical techniques for their detection and identification. Therefore, interest in ambient ionization mass spectrometry applied to NPS has grown in recent years, which is largely because it is relatively fast and simple to use and has a low operating cost. This review aims to provide a critique of the suitability of current ambient ionization techniques for the analysis of NPS in the forensic and clinical toxicology fields. Consideration is given to analytical performance and ease of implementation, including ionization efficiency, selectivity, sensitivity, quantification, analyte chemistry, molecular coverage, validation, and practicality.

中文翻译:

环境电离质谱法在新型精神活性物质分析中的应用

在过去的十年中,已经合成了大量与受控精神药物具有相似作用的药物,例如大麻、苯丙胺(苯丙胺)或麦角酰二乙胺。这些药物可以统称为新型精神活性物质 (NPS),用于娱乐目的。这些物质的新颖性,以及快速的出现率和结构可变性,使得它们的检测和法律控制极具挑战性,增加了对其检测和鉴定的快速和易于使用的分析技术的需求。因此,近年来,人们对应用于 NPS 的环境电离质谱法的兴趣有所增长,这在很大程度上是因为它相对快速、使用简单且运行成本低。本综述旨在对当前环境电离技术在法医和临床毒理学领域分析 NPS 的适用性提出批评。考虑了分析性能和易于实施,包括电离效率、选择性、灵敏度、定量、分析物化学、分子覆盖率、验证和实用性。
更新日期:2021-05-26
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