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Preoperative Albumin-Globulin Ratio and Its Association with Perioperative and Long-Term Outcomes in Patients Undergoing Pancreatoduodenectomy
Digestive Surgery ( IF 2.7 ) Pub Date : 2021-05-26 , DOI: 10.1159/000516278
Rajesh Shinde 1 , Manish Suresh Bhandare 1 , Vikram Chaudhari 1 , Varun Sarodaya 1 , Vandana Agarwal 2 , Shailesh Shrikhande 1
Affiliation  

Background: Systemic inflammatory response is involved in natural progression of cancers by different pathways. Albumin-globulin ratio (AGR) has been reported to have impact on prognosis in various solid tumors. Objective: To study the significance of AGR on perioperative and long-term outcomes in patients undergoing PD. Methods: This is a post hoc analysis of the pancreatic surgery database from January 2012 to March 2017. Cutoff value for AGR was calculated by using the receiver operating curve, and the study cohort was divided into group I (AGR ≥1) and group II (AGR #x3c;1). Two groups were compared for perioperative and long-term survival outcomes. Results: Two groups were comparable with respect to clinicodemographic variables. Groups I and II had similar perioperative outcomes (p #x3e; 0.05) like median hospital stay (14 vs. 15 days), clinically relevant postoperative pancreatic fistula (16.6 vs. 15.7%), hemorrhage (3.1 vs. 2.6%), bile leak (1.4 vs. 0.65%), overall morbidity (30.1 vs. 28.9%), and postoperative mortality (2.7 vs. 3.9%). With a median follow-up of 3 years, median survival, overall survival, and disease-free survival were similar in both groups. Conclusion: AGR at the cutoff value of ≥1 was not associated with adverse perioperative and long-term oncological outcomes after PD.
Dig Surg


中文翻译:

胰十二指肠切除术患者术前白蛋白-球蛋白比值及其与围手术期和远期预后的关系

背景:全身炎症反应通过不同途径参与癌症的自然进展。据报道,白蛋白球蛋白比 (AGR) 对各种实体瘤的预后有影响。目的:研究 AGR 对 PD 患者围手术期和远期预后的意义。方法:这是对2012年1月至2017年3月胰腺手术数据库的事后分析。使用受试者工作曲线计算AGR的临界值,将研究队列分为I组(AGR≥1)和II组(AGR #x3c;1)。比较两组的围手术期和长期生存结果。结果:两组在临床人口统计学变量方面具有可比性。I 组和 II 组具有相似的围手术期结果 ( p #x3e; 0.05),如中位住院时间(14 天对 15 天)、临床相关术后胰瘘(16.6 对 15.7%)、出血(3.1 对 2.6%)、胆汁漏(1.4 对 0.65%)、总体发病率(30.1 对 28.9%)和术后死亡率(2.7 对 3.9%)。中位随访 3 年,两组的中位生存期、总生存期和无病生存期相似。结论:临界值≥1 的 AGR 与 PD 后不良的围手术期和长期肿瘤学结果无关。
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更新日期:2021-05-26
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