In this study, a highly porous heparin-polyvinylalcohol@gold nanocomposite (H-PVA@Au) bandage was fabricated by incorporating Au into H-PVA hydrogel for burn injury. The effects of the H-PVA hydrogel and Au nanoparticle composition on the functional group and surface properties of the as-prepared bandages were characterized by Fourier transform infrared spectroscopy (FT-IR) and X-ray diffractometry (XRD). The morphology of the H-PVA hydrogel and H-PVA@Au were evaluated using a scanning electron microscope (SEM) and transmission electron microscope (TEM). A study of the material properties of H-PVA hydrogel has shown that the presence of Au nanoparticles improves its toughness. Prepared H-PVA@Au nanoporous dressing has indicated good antimicrobial activity against types of bacteria (Staphylococcus aureus and Escherichia coli) and excellent biocompatibility with human dermal fibroblast cells (HFFF2) suitable for biological applications. Additionally, in vivo experiments using Kunming mice showed it as-prepared H-PVA@Au nanocomposite dressings improved wound healing and triggered skin cell development alongside collagen growth. Synergistic effects of the H-PVA@Au nanocomposite hydrogel dressing material through in vivo experiments, such as its excellent hydrophilic design, strong bactericidal activity, biocompatibility and wound healing ability, make it a promising candidate for the treatment of burn injuries.

在这项研究中，通过将Au掺入H-PVA水凝胶中以烧伤，制备了高度多孔的肝素-聚乙烯醇@金纳米复合材料（H-PVA @ Au）绷带。H-PVA水凝胶和金纳米粒子组成对制备的绷带的官能团和表面性质的影响通过傅里叶变换红外光谱（FT-IR）和X射线衍射（XRD）表征。使用扫描电子显微镜（SEM）和透射电子显微镜（TEM）评估H-PVA水凝胶和H-PVA @ Au的形态。对H-PVA水凝胶的材料性能的研究表明，Au纳米颗粒的存在改善了其韧性。制备的H-PVA @ Au纳米多孔敷料对各种细菌（金黄色葡萄球菌和大肠杆菌（Escherichia coli）和与人皮肤成纤维细胞（HFFF2）的优异生物相容性，适用于生物应用。此外，使用昆明小鼠的体内实验表明，制备的H-PVA @ Au纳米复合敷料可改善伤口愈合，并触发皮肤细胞发育以及胶原蛋白的生长。H-PVA @ Au纳米复合水凝胶敷料通过体内实验具有协同作用，例如其优异的亲水性设计，强大的杀菌活性，生物相容性和伤口愈合能力，使其成为治疗烧伤的有前途的候选者。