Background. Endometriosis is a chronic and estrogen-dependent pelvic inflammatory disease, which may have various causes, such as oxidative stress. Dysmenorrhea, dyspareunia, and pelvic pain are well-known symptoms of endometriosis. The present clinical trial assessed the role of supplementation with antioxidant vitamins on the indices of oxidative stress as well as the severity of pain in women with endometriosis. Materials and Methods. We enrolled 60 reproductive-aged (15–45 years) women with pelvic pain in this triple-blind clinical trial. They had 1–3 stages of laparoscopic-proven endometriosis. The participants were randomized to group A (n = 30), given vitamin C (1000 mg/day, 2 tablets of 500 mg each) and vitamin E (800 IU/day, 2 tablets of 400 IU each) combination, or group B (n = 30), given placebo pills daily for 8 weeks. Results. Following treatment with vitamin C and vitamin E, we found a significant reduction in MDA and ROS compared with the placebo group. There was no significant decline in total antioxidant capacity after treatment. However, the severity of pelvic pain ( value <0.001), dysmenorrhea ( value <0.001), and dyspareunia ( value <0.001) significantly decreased in the treatment group after 8 weeks of supplementation. Conclusions. The present findings support the potential role of antioxidants in the management of endometriosis. The intake of vitamin C and vitamin E supplements effectively reduced dysmenorrhea severity and improved dyspareunia and severity of pelvic pain.

中文翻译：

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补充维生素C和维生素E对子宫内膜异位症妇女氧化应激指标的影响：一项随机，三盲安慰剂对照的临床试验

背景。子宫内膜异位症是一种慢性的，依赖雌激素的盆腔炎，可能有多种原因，例如氧化应激。痛经，痛经和骨盆痛是子宫内膜异位症的众所周知的症状。本临床试验评估了补充抗氧化剂维生素对子宫内膜异位症妇女氧化应激指标以及疼痛严重程度的作用。材料和方法。在这项三盲临床试验中，我们招募了60名育龄妇女（15-45岁）患有骨盆痛。他们有1-3个经腹腔镜证实的​​子宫内膜异位症。参与者被随机分为A组（n = 30），维生素C（1000毫克/天，2片各500毫克）和维生素E（800 IU /天，2片400 IU每片）组合或B组（n  = 30），给予安慰剂每天8周。结果。用维生素C和维生素E治疗后，与安慰剂组相比，我们发现MDA和ROS显着降低。治疗后总抗氧化剂能力没有明显下降。然而，在补充了8周后，治疗组的骨盆疼痛（<0.001），痛经（<0.001）和痛经（<0.001）的严重程度显着降低。结论。目前的发现支持抗氧化剂在子宫内膜异位症管理中的潜在作用。摄取维生素C和维生素E补充剂可有效减少痛经的严重程度，并改善痛经和骨盆疼痛的严重程度。