Chronic spontaneous urticaria (CSU) is a common skin disease which symptom is local pruritus and pain. In medicine, researchers take a certain point that the brain is the control center of CSU, but in previous experiments, the researchers found that cerebellum also had a certain effect on CSU. In order to find out the influence of CSU in the brain and cerebellum, we collected the brain resting-state fMRI data from 40 healthy controls and 32 CSU patients and used DPABI to preprocess. We calculated the entropy values of five scales by using multiscale entropy (MSE) and the average entropy values of two groups’ BOLD signals; 15 regions with significant differences were found which not only had a more detailed impact in the brain but also had an impact in the cerebellum, such as precentral gyrus, lenticular putamen, and vermis of cerebellum. In addition, we found that compared with the healthy controls, the entropy values of CSU patients showed two trends which need further study. The advantage of our experiment is that the multiscale entropy value is used to get more influence regions of CSU in the brain and cerebellum. The results of this paper may provide some help for the pathological study of CSU.

中文翻译：

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基于多尺度熵的慢性自发性荨麻疹特征研究

慢性自发性荨麻疹（CSU）是一种常见的皮肤病，症状是局部瘙痒、疼痛。在医学上，研究人员采取某种观点认为大脑是CSU的控制中心，但在之前的实验中，研究人员发现小脑对CSU也有一定的影响。为了了解CSU对大脑和小脑的影响，我们收集了40名健康对照者和32名CSU患者的大脑静息态fMRI数据，并使用DPABI进行预处理。我们利用多尺度熵（MSE）和两组BOLD信号的平均熵值计算了五个尺度的熵值；发现了15个存在显着差异的区域，这些区域不仅对大脑有更细致的影响，而且对小脑也有影响，如小脑的中央前回、豆状壳核和蚓部。此外，我们发现与健康对照相比，CSU患者的熵值表现出两个趋势，需要进一步研究。我们实验的优点是利用多尺度熵值来获得更多的CSU在大脑和小脑中的影响区域。本文的研究结果可为CSU的病理研究提供一定的帮助。