Abstract

Ischemic brain injuries are accompanied by the long-term changes in gene expression in the hippocampus, the limbic system structure, involved in the regulation of key aspects of the higher nervous activity, such as cognitive functions and emotions. The altered expression of genes and proteins encoded by them may be related to the development of post-ischemic psycho-emotional and cognitive disturbances. Activation of neuroinflammation following stroke in the hippocampus has been suggested to play an essential role in induction of long-lasting consequences. Identification of changes in the gene expression patterns after ischemia and investigation of the dynamics of these changes in the hippocampus are the necessary first steps toward understanding molecular pathways responsible for the development of post-stroke cognitive impairments and mental pathologies.

中文翻译：

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局灶性脑缺血后海马基因表达和神经炎症的变化：参与长期的认知和精神障碍。

摘要

缺血性脑损伤伴随着海马基因表达的长期变化，边缘系统结构的变化，涉及高级神经活动的关键方面的调节，例如认知功能和情绪。由它们编码的基因和蛋白质表达的改变可能与缺血后的心理情绪和认知障碍的发展有关。已经表明海马中风后神经炎症的激活在长期后果的诱导中起重要作用。