Three micellar-based mobile phases were developed and optimized for the simultaneous determination of certain partial dopamine agonists that are used to overcome the withdrawal symptoms of abused drugs, namely aripiprazole, pramipexole and piribedil. The studied drugs were separated using micellar liquid chromatography, hybrid micellar liquid chromatography (HMLC) and microemulsion liquid chromatography (MELC). The three developed mobile phases were studied to estimate their suitability for the measurement of log p-values of the studied drugs. Experimental determination of log P_m/w values using the three mobile phases demonstrates that HMLC is the mobile phase of choice since the obtained practical log P_m/w values were in accordance with the reported log P values, and calculated log P and log D values. An explanation of the obtained results was presented based on the separation retention mechanism for each chromatographic technique. Furthermore, the effect of the pH and the column temperature in HMLC on the practical log P_m/w values was studied. To verify its suitability for experimental measurement of log P_m/w , HMLC was subjected to full validation according to the United States Pharmacopeia.

开发并优化了三个基于胶束的流动相，用于同时测定某些部分的多巴胺激动剂，以克服滥用药物的戒断症状，​​即阿立哌唑，普拉克索和哌立贝定。使用胶束液相色谱，混合胶束液相色谱（HMLC）和微乳液液相色谱（MELC）分离所研究的药物。对三个开发的流动相进行了研究，以评估其对所研究药物的log p值测量的适用性。使用三个流动相进行对数P _{m / w}值的实验确定表明，由于获得了实际的对数P _{m / w}，HMLC是首选的流动相值与报告的log P值以及计算的log P和log D值一致。基于每种色谱技术的分离保留机理，对获得的结果进行了解释。此外，研究了HMLC中的pH和柱温对实际log P _{m / w}值的影响。以验证其是否适合的实验测量日志P _{M / W}  ， HMLC根据美国药典进行充分验证。