Mutations in genes encoding epigenetic modifiers are frequent in acute myelogenous leukemia (AML) and have been proposed to cause AML via activation of oncogenes and repression of tumor suppressors. Two studies now identify unexpected oncogenic mechanisms and therapeutic vulnerabilities in AML arising from mutations in genes encoding the epigenetic regulators DNMT3A and ASXL1.

中文翻译：

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AML的表观遗传阿喀琉斯之踵

编码表观遗传修饰物的基因突变在急性髓性白血病 (AML) 中很常见，并且已被提议通过激活癌基因和抑制肿瘤抑制因子来引起 AML。两项研究现在确定了由编码表观遗传调节因子 DNMT3A 和 ASXL1 的基因突变引起的 AML 中意想不到的致癌机制和治疗漏洞。