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Findings from recent studies by the Japan Aerospace Exploration Agency examining musculoskeletal atrophy in space and on Earth
npj Microgravity ( IF 5.1 ) Pub Date : 2021-05-26 , DOI: 10.1038/s41526-021-00145-9
Satoshi Furukawa , Masahiro Chatani , Atsushi Higashitani , Akira Higashibata , Fuminori Kawano , Takeshi Nikawa , Takuro Numaga-Tomita , Toshihiko Ogura , Fuminori Sato , Atsuko Sehara-Fujisawa , Masahiro Shinohara , Toru Shimazu , Satoru Takahashi , Haruko Watanabe-Takano

The musculoskeletal system provides the body with correct posture, support, stability, and mobility. It is composed of the bones, muscles, cartilage, tendons, ligaments, joints, and other connective tissues. Without effective countermeasures, prolonged spaceflight under microgravity results in marked muscle and bone atrophy. The molecular and physiological mechanisms of this atrophy under unloaded conditions are gradually being revealed through spaceflight experiments conducted by the Japan Aerospace Exploration Agency using a variety of model organisms, including both aquatic and terrestrial animals, and terrestrial experiments conducted under the Living in Space project of the Japan Ministry of Education, Culture, Sports, Science, and Technology. Increasing our knowledge in this field will lead not only to an understanding of how to prevent muscle and bone atrophy in humans undergoing long-term space voyages but also to an understanding of countermeasures against age-related locomotive syndrome in the elderly.



中文翻译:

日本宇宙航空研究开发机构(Japan Aerospace Exploration Agency)最近研究的结果,研究太空和地球上的肌肉骨骼萎缩

肌肉骨骼系统为身体提供正确的姿势,支撑,稳定性和活动性。它由骨骼,肌肉,软骨,肌腱,韧带,关节和其他结缔组织组成。如果没有有效的对策,在微重力作用下长时间的太空飞行会导致明显的肌肉和骨骼萎缩。在日本,日本宇航局采用多种模型生物(包括水生动物和陆生动物)进行太空飞行实验,以及在日本的“生活在太空”项目中进行的陆生实验,逐渐揭示了在空载条件下这种萎缩的分子和生理机制。日本教育,文化,体育,科学和技术省。

更新日期:2021-05-26
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