Fibroblastic stromal cells are as diverse, in origin and function, as the niches they fashion in the mammalian body. This cellular variety impacts the spectrum of responses elicited by the immune system. Fibroblast influence on the immune system keeps evolving our perspective on fibroblast roles and functions beyond just a passive structural part of organs. This review discusses the foundations of fibroblastic stromal-immune crosstalk, under the scope of stromal heterogeneity as a basis for tissue-specific tutoring of the immune system. Focusing on the skin as a relevant immunological organ, we detail the complex interactions between distinct fibroblast populations and immune cells that occur during homeostasis, injury repair, scarring, and disease. We further review the relevance of fibroblastic stromal cell heterogeneity and how this heterogeneity is central to regulate the immune system from its inception during embryonic development into adulthood.

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成纤维细胞作为免疫系统的同盟

成纤维细胞基质细胞在起源和功能上与它们在哺乳动物体内形成的壁龛一样多样化。这种细胞多样性影响免疫系统引发的反应谱。成纤维细胞对免疫系统的影响不断发展我们对成纤维细胞作用和功能的看法，而不仅仅是器官的被动结构部分。本综述在基质异质性范围内讨论了成纤维细胞基质免疫串扰的基础，作为免疫系统组织特异性指导的基础。将皮肤作为相关的免疫器官，我们详细介绍了在稳态、​​损伤修复、疤痕形成和疾病过程中发生的不同成纤维细胞群与免疫细胞之间的复杂相互作用。