Introduction:

Simple markers are required to recognize older adults at higher risk for neurodegenerative disease. Mild behavioural impairment (MBI) and plasma β-amyloid (Aβ) have been independently implicated in the development of incident cognitive decline and dementia. Here we studied the associations between MBI and plasma Aβ₄₂/Aβ₄₀.

Methods:

Participants with normal cognition (n = 86) or mild cognitive impairment (n = 53) were selected from the Alzheimer’s Disease Neuroimaging Initiative. MBI scores were derived from Neuropsychiatric Inventory items. Plasma Aβ₄₂/Aβ₄₀ ratios were assayed using mass spectrometry. Linear regressions were fitted to assess the association between MBI total score as well as MBI domain scores with plasma Aβ₄₂/Aβ₄₀.

Results:

Lower plasma Aβ₄₂/Aβ₄₀ was associated with higher MBI total score (p = 0.04) and greater affective dysregulation (p = 0.04), but not with impaired drive/motivation (p = 0.095) or impulse dyscontrol (p = 0.29) MBI domains.

Conclusion:

In persons with normal cognition or mild cognitive impairment, MBI was associated with low plasma Aβ₄₂/Aβ₄₀. Incorporating MBI into case detection may help capture preclinical and prodromal Alzheimer’s disease.

中文翻译：

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轻度行为障碍中的血浆 β-淀粉样蛋白 – 阿尔茨海默病连续体的神经精神症状

介绍：

需要简单的标记来识别神经退行性疾病风险较高的老年人。轻度行为障碍 (MBI) 和血浆 β-淀粉样蛋白 (Aβ) 与认知能力下降和痴呆的发生独立相关。在这里，我们研究了 MBI 与血浆 Aβ ₄₂ /Aβ ₄₀之间的关联。

方法：

认知正常 (n = 86) 或轻度认知障碍 (n = 53) 的参与者选自阿尔茨海默病神经影像学倡议。MBI 评分来自神经精神库存项目。使用质谱分析血浆Aβ ₄₂ /Aβ _40比率。拟合线性回归以评估 MBI 总分以及 MBI 域得分与血浆 Aβ ₄₂ /Aβ ₄₀之间的关联。

结果：

较低的血浆 Aβ ₄₂ /Aβ ₄₀与较高的 MBI 总分 ( p = 0.04) 和较大的情感失调 ( p = 0.04) 相关，但与驱动/动机受损 ( p = 0.095) 或冲动失控 ( p = 0.29) MBI无关域。

结论：

在认知正常或轻度认知障碍的人中，MBI 与低血浆 Aβ ₄₂ /Aβ ₄₀相关。将 MBI 纳入病例检测可能有助于捕获临床前和前驱阿尔茨海默病。