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The Neutrophil-to-Monocyte Ratio and Platelet-to-White Blood Cell Ratio Represent Novel Prognostic Markers in Patients with Pancreatic Cancer
Gastroenterology Research and Practice ( IF 2 ) Pub Date : 2021-05-25 , DOI: 10.1155/2021/6693028
Feng Tang 1 , Penghui Dai 1 , Qiongqiong Wei 1 , Ke Gan 1 , Zijie Wang 1 , Huan Chen 1 , Ting Li 1 , Muhan Lv 1 , Mingming Deng 1 , Gang Luo 1
Affiliation  

Background. Inflammation plays an important role in the development of tumors. Several serum based-markers and ratios have been investigated for their prognostic value in pancreatic cancer. However, the prognostic value of the neutrophil-to-monocyte ratio (NMR) and platelet-to-white blood cell ratio (PWR) for patients with pancreatic cancer has scarcely been investigated. Methods. From October 2013 to November 2018, a retrospective cohort study was performed on 269 pancreatic cancer patients without treatment. Receiver operating characteristic curves were generated, and areas under the curve were compared for the evaluation of the discriminatory ability of inflammation-based prognostic scoring systems. Kaplan-Meier curves and the Cox proportional hazard model were employed to analyze the relationships among NMR, PWR, and overall survival (OS). Results. The optimal cutoff values of NMR and PWR were 48 and 6, respectively. In univariate analysis, the survival time of and was shorter than that of and in patients with pancreatic cancer (). In Cox univariate and multivariate analyses, NMR (hazard ratio (HR), 9.095; 95% confidence interval (CI), 3.64–22.72; ) and PWR (HR, 8.230; 95% CI, 3.32–20.43; ) were significantly correlated with OS. Conclusions. The current study demonstrated that NMR and PWR may serve as novel and promising inflammatory prognostic scores for patients with pancreatic cancer. Elevated NMR (>48) and depressed PWR (<6) were independently associated with poor prognosis in patients with pancreatic cancer.

中文翻译:

中性粒细胞与单核细胞的比率和血小板对白细胞的比率代表胰腺癌患者的新的预后标志物。

背景。炎症在肿瘤的发展中起重要作用。已经研究了几种血清标志物和比率在胰腺癌中的预后价值。然而,很少研究嗜中性粒细胞与单核细胞的比率(NMR)和血小板对白血球的比率(PWR)对胰腺癌患者的预后价值。方法。从2013年10月至2018年11月,对269名未经治疗的胰腺癌患者进行了一项回顾性队列研究。生成受试者工作特征曲线,并比较曲线下的面积,以评估基于炎症的预后评分系统的辨别能力。采用Kaplan-Meier曲线和Cox比例风险模型分析NMR,PWR和总生存率(OS)之间的关系。结果。NMR和PWR的最佳截止值分别为48和6。在单因素分析中, 短于 在胰腺癌患者中()。在Cox单变量和多变量分析中,NMR(危险比(HR)为9.095; 95%置信区间(CI)为3.64–22.72; N = 9.64。和PWR(HR,8.230; 95%CI,3.32-20.43;与OS显着相关。结论。当前的研究表明,NMR和PWR可以作为胰腺癌患者的新颖且有希望的炎症预后评分。胰腺癌患者的NMR升高(> 48)和PWR降低(<6)与不良预后独立相关。
更新日期:2021-05-25
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