Abstract

Two derivatives of adamantane benzenesulfamide have been synthesized and studied: N-adamantane-1-yl-2,4,6-trimethyl-benzenesulfamide (1) and N-adamantane-1-yl-4-methoxy-benzenesulfamide (2). Crystal structures 1 and 2 are solved using X-ray diffraction (XRD) analysis. The solubilities of compounds in a phosphate buffer solution with pH 7.4, 1-octanol, and n-hexane are determined at several temperature points using isothermal saturation. The values of Gibbs energy, enthalpy, and entropy of solubility of the compounds at 298 K are determined.

中文翻译：

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两种新型磺酰胺金刚烷衍生物的晶体结构和理化特性

摘要

合成并研究了金刚烷苯磺酰胺的两种衍生物：N-金刚烷-1-基-2,4,6-三甲基-苯磺酰胺（1）和N-金刚烷-1-基-4-甲氧基-苯磺酰胺（2）。使用X射线衍射（XRD）分析来解析晶体结构1和2。在pH 7.4，1-辛醇的磷酸盐缓冲溶液的化合物的溶解度，和Ñ正己烷在使用等温饱和几个温度点来确定。确定化合物在298 K时的吉布斯能量，焓和溶解度熵的值。