Aims

Time in range (TIR), an index of glycemic control and also blood glucose fluctuation, obtained from continuous glucose monitoring (CGM), has been increasing its importance along with the spread of CGM in recent years. For a while, glycated albumin (GA) has been also used as a glycemic control index during about 2-weeks in routine clinical practice. It has not yet been confirmed under optimal condition whether TIR and GA correlates. Clarification of the correlation between TIR and GA, which was measured immediately after 2-weeks of CGM, might be a finding that further supports the utility of TIR.

Methods

GA was measured at the conclusion of 2-week CGM in 71 diabetes outpatients at our hospital, and the correlation between GA and indices such as TIR obtained from CGM was statistically analyzed.

Results

It was found that TIR and time above range (TAR) were significantly correlated with GA. Upon performing multiple regression analysis, TIR, TAR and BMI. indicated a significant regression coefficient with respect to GA.

Conclusions

These findings further support the utility of TIR as a marker of glycemic control that it might also be correlated with GA, and also suggest a relation between GA and blood glucose fluctuation.

中文翻译：

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范围内的时间与连续血糖监测 2 周后立即测量的糖化白蛋白相关

目标

从连续血糖监测 (CGM) 获得的范围时间 (TIR) 是血糖控制和血糖波动的指标，随着近年来 CGM 的普及，其重要性日益增加。一段时间以来，糖化白蛋白 (GA) 也被用作常规临床实践中约 2 周的血糖控制指标。在最佳条件下尚未确认 TIR 和 GA 是否相关。在 CGM 2 周后立即测量的 TIR 和 GA 之间相关性的澄清可能是进一步支持 TIR 效用的发现。

方法

在我院71例糖尿病门诊患者2周CGM结束时测量GA，统计分析GA与CGM获得的TIR等指标的相关性。

结果

发现 TIR 和超出范围的时间 (TAR) 与 GA 显着相关。在执行多元回归分析后，TIR、TAR 和 BMI。表示关于 GA 的显着回归系数。

结论

这些发现进一步支持了 TIR 作为血糖控制标志物的效用，它也可能与 GA 相关，并且还表明 GA 与血糖波动之间的关系。