Abstract

Background

Alcohol use disorder (AUD) is a psychiatric disorder characterized by excessive and uncontrolled drinking that causes distress and has damaging consequences for men and women of all ages. It is one of the four most disabling diseases and it affects approximately 14.6 million persons in Europe.

Objectives

Objective of this study is to investigate changes in platelet serotonin concentration after four weeks of alcohol abstinence in regards to the genotype of the serotonin transporter.

Methods

A total of 154 patients with AUD were included in the study. Platelet serotonin concentrations were assessed by enzyme-linked immunosorbent assay. Genotype of serotonin transporter promoter polymorphism was determined by the polymerase chain reaction-based method.

Results

We did not establish a statistically significant main effect of serotonin transporter polymorphism on platelet serotonin concentration after four weeks of abstinence.

Conclusion

Aforementioned finding is in line with previous research suggesting a complex relationship between serotonin transporter gene and platelet serotonin levels, and congruent with the well-established genotype interaction with numerous other factors, such as sex, ethnicity, education level, and stressful life events.

中文翻译：

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戒酒 4 周后血小板血清素浓度的变化取决于血清素转运蛋白的基因型

摘要

背景

酒精使用障碍 (AUD) 是一种精神疾病，其特征是过度和不受控制的饮酒，会导致痛苦并对所有年龄段的男性和女性造成破坏性后果。它是四种最致残的疾病之一，在欧洲影响着大约 1460 万人。

目标

本研究的目的是调查戒酒 4 周后血小板血清素浓度的变化与血清素转运蛋白的基因型有关。

方法

共有 154 名 AUD 患者被纳入研究。通过酶联免疫吸附试验评估血小板血清素浓度。5-羟色胺转运蛋白启动子多态性的基因型通过基于聚合酶链反应的方法确定。

结果

在禁欲 4 周后，我们没有确定 5-羟色胺转运蛋白多态性对血小板 5-羟色胺浓度的显着主要影响。

结论

上述发现与先前的研究一致，即血清素转运蛋白基因和血小板血清素水平之间存在复杂关系，并且与已确立的基因型与许多其他因素（如性别、种族、教育水平和压力性生活事件）的相互作用一致。