Extracellular vesicles derived from mesenchymal stem cells containing microRNA-381 protect against spinal cord injury in a rat model via the BRD4/WNT5A axis.,Bone & Joint Research

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Extracellular vesicles derived from mesenchymal stem cells containing microRNA-381 protect against spinal cord injury in a rat model via the BRD4/WNT5A axis.
Bone & Joint Research ( IF 4.6 ) Pub Date : 2021-5-25 , DOI: 10.1302/2046-3758.105.bjr-2020-0020.r1
Xufeng Jia ₁ , Guangping Huang ₁ , Shaohua Wang ₁ , Miao Long ₁ , Xiaojun Tang ₁ , Daxiong Feng ₂ , Qingzhong Zhou ₂

Affiliation

Non-coding microRNA (miRNA) in extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) may promote neuronal repair after spinal cord injury (SCI). In this paper we report on the effects of MSC-EV-microRNA-381 (miR-381) in a rodent model of SCI.

中文翻译：

在大鼠模型中，源自骨髓间充质干细胞的含有microRNA-381的细胞外囊泡可通过BRD4 / WNT5A轴防止脊髓损伤。

源自间充质干细胞（MSC）的细胞外囊泡（EVs）中的非编码microRNA（miRNA）可能会促进脊髓损伤（SCI）后的神经元修复。在本文中，我们报道了MSC-EV-microRNA-381（miR-381）在SCI啮齿动物模型中的作用。

更新日期：2021-05-26

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