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High strength and strain alginate fibers by a novel wheel spinning technique for knitting stretchable and biocompatible wound-care materials
Biomaterials Advances ( IF 7.9 ) Pub Date : 2021-05-25 , DOI: 10.1016/j.msec.2021.112204
Zhongda Chen 1 , Jun Song 1 , Yumin Xia 1 , Yuwei Jiang 1 , Luis Larrea Murillo 2 , Olga Tsigkou 1 , Tao Wang 2 , Yi Li 1
Affiliation  

Alginate fibrous materials have been applied as wound dressing to enhance wound healing due to its nontoxic, biodegradable, and hemostatic nature. Conventional nonwoven fabrication tactics, however, showed weakness in inflammation, degradation stability and mechanical properties. Herein, the wet-spun alginate fibers were prepared by a novel wheel spinning technique, then knitted into wound dressing. Benefiting from optimized wet spinning parameters and the agglomeration of alginate multimers, the fibers were endowed with elevated mechanical performances and biodegradability, which allowed for the feasibility of knitting wound-care materials. Using the new wheel spinning technique, high strength alginate fibers with 173 MPa were produced with breaking strain up to 18% and toughness of 16.16 MJ*m−3. Meanwhile, alginate fibers with high breaking strain reaching 35% were produced with tensile strength of 135 MPa and toughness of 37.47 MJ*m−3. The overall mechanical performances of these alginate fibers with high breaking strain are significantly higher (up to 2 times) than those published in the literature in term of toughness. In vitro degradation evaluation revealed that this wet spun fibrous dressing had good aqueous absorbency (50%) and sustained biodegradation properties. Furthermore, the consequent cell viability study also proved that this alginate knitted fabric is biocompatible for being applied as wound dressing.



中文翻译:

高强度和应变藻酸盐纤维,通过新颖的纺纱技术编织可拉伸和生物相容的伤口护理材料

藻酸盐纤维材料由于其无毒、可生物降解和止血的特性,已被用作伤口敷料以促进伤口愈合。然而,传统的非织造布制造策略在炎症、降解稳定性和机械性能方面表现出弱点。在这里,湿纺海藻酸盐纤维是通过一种新颖的轮纺技术制备的,然后编织成伤口敷料。得益于优化的湿纺参数和藻酸盐多聚体的团聚,这些纤维具有更高的机械性能和生物降解性,这使得针织伤口护理材料成为可能。使用新的轮式纺丝技术,生产出173 MPa的高强度海藻酸盐纤维,断裂应变高达18%,韧性达16.16 MJ*m -3. 同时,生产的海藻酸盐纤维具有高达35%的断裂应变,拉伸强度为135 MPa,韧性为37.47 MJ*m -3。这些具有高断裂应变的藻酸盐纤维的整体机械性能在韧性方面明显高于(高达 2 倍)文献中公开的纤维。体外降解评估表明,这种湿纺纤维敷料具有良好的吸水性 (50%) 和持续的生物降解特性。此外,随后的细胞活力研究也证明这种藻酸盐针织物具有生物相容性,可用作伤口敷料。

更新日期:2021-05-30
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