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Ethanolamine bacterial microcompartments: from structure, function studies to bioengineering applications
Current Opinion in Microbiology ( IF 5.4 ) Pub Date : 2021-05-24 , DOI: 10.1016/j.mib.2021.04.008
Anaya Pokhrel 1 , Sun-Young Kang 1 , Claudia Schmidt-Dannert 1
Affiliation  

Two decades of structural and functional studies have revealed functions, structures and diversity of bacterial microcompartments. The protein-based organelles encapsulate diverse metabolic pathways in semipermeable, icosahedral or pseudo-icosahedral shells. One of the first discovered and characterized microcompartments are those involved in ethanolamine degradation. This review will summarize their function and assembly along with shared and unique characteristics with other microcompartment types. The modularity and self-assembling properties of their shell proteins make them valuable targets for bioengineering. Advances and prospects for shell protein engineering in vivo and in vitro for synthetic biology and biotechnology applications will be discussed.



中文翻译:

乙醇胺细菌微室:从结构、功能研究到生物工程应用

二十年的结构和功能研究揭示了细菌微区室的功能、结构和多样性。基于蛋白质的细胞器将多种代谢途径封装在半透性、二十面体或假二十面体壳中。最早发现和表征的微隔室之一是参与乙醇胺降解的微隔室。本综述将总结它们的功能和组装,以及与其他微型隔室类型的共享和独特特征。其壳蛋白的模块化和自组装特性使其成为生物工程的重要目标。将讨论用于合成生物学和生物技术应用的体内外壳蛋白工程的进展和前景。

更新日期:2021-05-24
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