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Two New Pterocarpans from Lespedeza tomentosa
Chemistry of Natural Compounds ( IF 0.8 ) Pub Date : 2021-05-24 , DOI: 10.1007/s10600-021-03385-z
Yongsoo Kwon , Heejung Yang , Wanjoo Chun , Myong Jo Kim , Iklas A. Khan

A phytochemical study on the MeOH extract of Lespedeza tomentosa roots led to the discovery of two new pterocarpans (labelled tomentocarpan A and B), along with three known pterocarpans and a flavanone. The structures of the two new compounds were found to be (6aR,11aR)-1-methoxy-8-hydroxy-2′,2′-dimethylpyrano[5′,6′:2,3]-2′′,2′′-dimethylpyrano[6′′,5′′:9,10]pterocarpan (5), and 1-methoxy-8-hydroxy-2′,2′-dimethylpyrano[5′,6′:2,3]-2′′,2′′-dimethylpyrano[6′′,5′′:9,10]pterocarp-6a(11a)-ene (6), based on comprehensive spectral and physical property analyses. Compounds 5 and 6 showed butyrylcholinesterase inhibitory activities with IC50 values of 0.50 and 0.62 mM, respectively.



中文翻译:

两种新的紫檀(Lespedeza tomentosa)

Lespedeza tomentosa根的MeOH提取物进行的植物化学研究导致发现了两个新的罗汉松(标记为tomentocarpan A和B),以及三个已知的罗汉松和黄烷酮。发现这两种新化合物的结构为(6aR,11aR)-1-甲氧基-8-羟基-2',2'-二甲基吡喃并[5',6':2,3] -2'',2' ′-二甲基吡喃并[6′,5′′:9,10] carp果烷(5)和1-甲氧基-8-羟基-2′,2′-二甲基吡喃并[5′,6′:2,3] -2基于综合的光谱和物理性质分析,′′,2′′-二甲基吡喃并[6′′,5′′:9,10] pt果-6a(11a)-烯(6)。化合物56表现出丁酰胆碱酯酶抑制活性,IC 50值分别为0.50和0.62 mM。

更新日期:2021-05-24
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