The present study aimed to classify lymphoid neoplasms according to the latest World Health Organization (WHO) classification and outlining the distribution in Nigeria of different entities. Additionally, the study describes the prevalence of lymphoid neoplasms associated with Epstein-Barr virus (EBV) infection in the Nigerian population. We collected 152 formalin-fixed paraffin-embedded (FFPE) tissues diagnosed as lymphoma from 2008 to 2018, coming from three different institutions located within three geopolitical zone in Nigeria. These institutions included the University College Hospital (UCH), Ibadan, Oyo State, the Enugu State University of Science and Technology Teaching Hospital (ESUTH), Enugu, Enugu State, and the Meena Histopathology and Cytology Laboratory (MHCL), Jos, Plateau State. From the total 152 cases retrieved, 50 were excluded due to insufficient tissue materials or inconclusive antigen reactivity. We confirmed 66 (64.7%) cases as lymphomas out of the remaining 102 FFPE with a male to female ratio of 2:1 and a mean age of 44.4 years. Ten entities were identified, and of these, chronic lymphocytic leukemia (CLL) was the most prevalent category (34.8%). For the diffuse large B-cell lymphomas not otherwise specified (DLBCL, NOS), the germinal centre B–cell type was the most common (71.4%). Ten lymphoma cases (15.2%) were positive for Epstein-Barr virus (EBV), most of which were Hodgkin lymphoma (HL). CLL was common in the Hausa ethnic group, HL in the Yoruba ethnic group, while the Igbo ethnic group had an equal distribution of CLL, HL, and DLBCL diagnosis. Although the distribution of lymphomas in Nigeria shares some similarities with those of other countries, we described distinct features of some subtypes of lymphomas. Also, the study underscores the need for a more precise diagnosis and classification of lymphoid neoplasms in Nigeria using the latest WHO classification.

中文翻译：

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根据世界卫生组织分类（2016年）的淋巴样肿瘤特征的不同模式以及尼日利亚人群中相关的爱泼斯坦-巴尔病毒感染的患病率

本研究旨在根据最新的世界卫生组织（WHO）分类对淋巴样肿瘤进行分类，并概述不同实体在尼日利亚的分布。此外，该研究还描述了尼日利亚人群中与爱泼斯坦-巴尔病毒（EBV）感染相关的淋巴样肿瘤的患病率。我们从2008年至2018年收集了152个福尔马林固定石蜡包埋（FFPE）组织，这些组织被诊断为淋巴瘤，来自尼日利亚三个地缘政治区内的三个不同机构。这些机构包括位于奥约州伊巴丹的大学学院医院（UCH），位于Enugu State的Enugu州立科学技术大学教学医院（ESUTH）和位于高原州Jos的Meena组织病理学和细胞学实验室（MHCL） 。在总共152起案件中，由于组织材料不足或抗原反应性不确定，排除了50例。我们在剩下的102例FFPE中确诊了66例（64.7％）淋巴瘤，男女之比为2：1，平均年龄为44.4岁。确定了十个实体，其中慢性淋巴细胞性白血病（CLL）是最普遍的类别（34.8％）。对于未另作说明的弥漫性大B细胞淋巴瘤（DLBCL，NOS），生发中心B细胞类型最为常见（71.4％）。十例淋巴瘤病例（15.2％）的爱泼斯坦-巴尔病毒（EBV）呈阳性，其中多数为霍奇金淋巴瘤（HL）。在豪萨族中，CLL很常见，在约鲁巴族中是HL，而伊博族则具有相同的CLL，HL和DLBCL诊断。尽管尼日利亚的淋巴瘤分布与其他国家有相似之处，但我们描述了某些淋巴瘤亚型的独特特征。此外，该研究强调，需要使用最新的WHO分类对尼日利亚的淋巴瘤进行更精确的诊断和分类。