Sulfonylurea herbicides are the most widely used herbicides in the world. They have the advantages of high efficiency, good selectivity, and no toxicity to human and animals. In this study, sulfonylureas containing imidazole heterocycles were synthesized on the basis of computer simulation of molecular docking, and the biological activity was evaluated. It shows that the compound has a good inhibitory effect on the ALS and a certain inhibitory effect on the phytopathogenic fungi of Curvularia lunata and Curvularia mebaldsii. Its inhibitory rate at concentration of 50 mg/L is similar to that of the carbendazim. This research provides the basis for further optimization of the structure of imidazolium heterocyclic sulfonylurea and the synthesis of its derivatives.

中文翻译：

---

咪唑杂环磺酰脲类化合物的合成及生物活性评价

磺酰脲类除草剂是世界上使用最广泛的除草剂。它们具有效率高、选择性好、对人畜无毒等优点。本研究在分子对接的计算机模拟的基础上合成了含有咪唑杂环的磺酰脲类药物，并对其生物活性进行了评价。它表明，该化合物具有对ALS良好的抑制效果和对的植物病原真菌有一定抑制作用新月弯孢霉和弯孢mebaldsii 。其在50mg/L浓度时的抑菌率与多菌灵相似。该研究为进一步优化咪唑鎓杂环磺酰脲的结构及其衍生物的合成提供了依据。