Two new dipimprinine alkaloids dipimprinine E (1) and dipimprinine F (2) were isolated from Streptomyces sp. 44414B. The structure was elucidated by extensive spectroscopic analysis, including ESI-MS, HR-MS, and 1D and 2D NMR experiments. Dipimprinines F (2) showed cytotoxic activities against three tumor cell lines, including A-875, Hep G2, and H-460, with IC₅₀ values of 26.4, 0.5, and 9.0 μg ml⁻¹, respectively.

中文翻译：

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来自土壤来源的链霉菌属的两种新的二苯丙胺生物碱。44414B

从链霉菌属中分离得到了两种新的地平比宁生物碱地平比宁E( 1 )和地平比宁F( 2 ) 。44414B。通过广泛的光谱分析阐明了结构，包括 ESI-MS、HR-MS 以及 1D 和 2D NMR 实验。Dipimprinines F ( 2 ) 对三种肿瘤细胞系显示出细胞毒活性，包括 A-875、Hep G2 和 H-460，IC ₅₀值分别为 26.4、0.5 和 9.0 μg ml ^-1。