Introduction

Among patients with congenital heart disease, those born with only a single working ventricle represent a particularly complex sub-population, typically requiring multiple surgeries and suffering from high levels of mortality and morbidity. Their cardiac care is complex and has evolved considerably since surgical palliation was first introduced more than 50 years ago. Improvements in treatment have been driven both by growing clinical experience and by knowledge gained through experimental and computational studies of blood flow in these patients. The Cardiovascular Fluid Mechanics Lab at the Georgia Institute of Technology, founded 30 years ago by Dr. Ajit Yoganathan, has pioneered work in this field.

Methods

In this review, key contributions of Dr. Yoganathan's Cardiovascular Fluid Dynamics Lab are surveyed, including experimental flow loop studies as well as computational fluid dynamics analyses that address many of the critical challenges that cardiologists and surgeons face in treating these patients, including how to reconstruct cardiovascular anatomy to minimize power loss, balance blood flow distribution at key bifurcation points, and avoid other unfavorable hemodynamic conditions.

Conclusions

Among many contributions in this field, work from the Cardiovascular Fluid Mechanics Lab has led to novel medical devices and patient-specific computational modeling workflows and software tools. These key contributions from this group have enhanced our understanding of the physiology and management of single-ventricle patients.

中文翻译：

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向 Ajit Yoganathan 的心血管流体力学实验室致敬：其对我们理解单心室患者生理学和管理的贡献的调查

介绍

在先天性心脏病患者中，出生时只有一个工作心室的患者代表了一个特别复杂的亚群，通常需要多次手术，并且死亡率和发病率都很高。他们的心脏护理很复杂，并且自 50 多年前首次引入外科姑息治疗以来已经有了很大的发展。不断增长的临床经验和通过对这些患者的血流进行实验和计算研究获得的知识推动了治疗的改进。乔治亚理工学院心血管流体力学实验室由 Ajit Yoganathan 博士于 30 年前创立，开创了该领域的工作。

方法

在这篇综述中，调查了 Yoganathan 博士心血管流体动力学实验室的主要贡献，包括实验性流动回路研究以及计算流体动力学分析，这些分析解决了心脏病专家和外科医生在治疗这些患者时面临的许多关键挑战，包括如何重建心血管解剖学以最大程度地减少功率损失，平衡关键分叉点的血流分布，并避免其他不利的血流动力学条件。

结论

在该领域的众多贡献中，心血管流体力学实验室的工作导致了新的医疗设备和患者特定的计算建模工作流程和软件工具。该小组的这些关键贡献增强了我们对单心室患者的生理学和管理的理解。