Abstract

Sepsis is one of the most serious problems in modern medicine. Long-term outcomes in septic shock patients are very discouraging: 75% individuals who survived sepsis and septic shock demonstrate signs of organ failure and experience persistent functional deficit. Acute sepsis and its management in an intensive care unit (ICU) to a great extent determine the pathogenesis of further complications. We believe that the concept of phenoptosis proposed by Prof. Skulachev deserves a special attention from anesthesiologists and ICU doctors. According to this concept, septic shock is a suicidal mechanism of programmed organism death, which protects human population from dangerously infected individuals. The article suggests a potential approach to the sepsis treatment based on the notion that septic shock can be prevented by identification and blockade of receptors involved in the processing of phenoptotic signal induced by lipopolysaccharide and other substances that initiate septic shock. In view of this, the search for agents that can block molecular mechanisms of the phenoptotic signal transmission seems very promising.

中文翻译：

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败血症后的长期结果

摘要

败血症是现代医学中最严重的问题之一。败血性休克患者的长期结局非常令人沮丧：败血症和败血性休克幸存者中有75％的人表现出器官衰竭的迹象，并经历持续的功能缺陷。重症监护病房（ICU）的急性败血症及其治疗在很大程度上决定了进一步并发症的发病机理。我们认为，Skulachev教授提出的表皮凋亡概念值得麻醉学家和ICU医生的特别注意。根据这个概念，败血性休克是程序性生物死亡的自杀机制，可以保护人类免受危险感染的人的侵害。该文章提出了一种潜在的脓毒症治疗方法，其依据是通过鉴定和阻断参与脂多糖和其他引发败血性休克的物质诱导的表型信号处理的受体，可以预防败血性休克。鉴于此，寻找可以阻断表型信号传导分子机制的药物似乎非常有前途。