Soil-transmitted helminth (STH) infections and diarrheal illness affect billions of people yearly. We conducted a cross-sectional survey in Nueva Santa Rosa, Guatemala to identify factors associated with STH infections and diarrhea using univariable and multivariable logistic regression models. On multivariable analyses, we found associations between STH infections and two factors: school-aged children (odds ratio (OR) vs. adults: 2.35, 95% CI 1.10–4.99) and household drinking water supply classified as ‘other improved’ (OR vs. ‘improved’: 7.00, CI 1.22–40.14). Finished floors in the household vs. natural floors were highly protective (OR 0.16, CI 0.05–0.50) for STH infection. In crowded households (>2.5 people/bedroom), observing water present at handwashing stations was also protective (OR 0.32, CI 0.11–0.98). When adjusted for drying hands, diarrhea was associated with preschool-age children (OR vs. adults: 3.33, CI 1.83–6.04), spending >10 min per round trip collecting water (OR 1.90, CI 1.02–3.56), and having a handwashing station ≤10 m near a sanitation facility (OR 3.69, CI 1.33–10.21). Our study indicates that familiar WASH interventions, such as increasing drinking water quantity and water at handwashing stations in crowded homes, coupled with a hygiene intervention like finished flooring may hold promise for STH and diarrhea control programs.

土壤传播的蠕虫（STH）感染和腹泻病每年影响数十亿人。我们在危地马拉Nueva Santa Rosa进行了横断面调查，以使用单变量和多变量logistic回归模型确定与STH感染和腹泻相关的因素。在多变量分析中，我们发现了STH感染与两个因素之间的关联：学龄儿童（优势比（OR）与成人：2.35，95％CI 1.10–4.99）和被归类为“其他改善”的家庭饮用水供应（OR与“已改进”：7.00，CI为1.22–40.14）。与天然地板相比，家庭用成品地板对STH感染具有高度防护性（OR 0.16，CI 0.05–0.50）。在拥挤的家庭（每间卧室超过2.5人）中，观察洗手站上的水也是有保护作用的（OR 0.32，CI 0.11-0.98）。调整好干手后，腹泻与学龄前儿童相关（OR与成人：3.33，CI为1.83–6.04），每次往返花费> 10分钟收集水（OR 1.90，CI为1.02–3.56），并且在附近洗手站≤10m卫生设施（OR 3.69，CI 1.33–10.21）。我们的研究表明，熟悉的WASH干预措施，例如在拥挤的房屋中增加饮用水量和洗手站的水量，再加上像地板铺成地板这样的卫生干预措施，可能会为STH和腹泻控制计划带来希望。