Over the past year, numerous studies in the peer reviewed and preprint literature have reported on the virological, epidemiological and clinical characteristics of the coronavirus, SARS-CoV-2. To date, 25 studies have investigated and identified SARS-CoV-2-derived T cell epitopes in humans. Here, we review these recent studies, how they were performed, and their findings. We review how epitopes identified throughout the SARS-CoV2 proteome reveal significant correlation between number of epitopes defined and size of the antigen provenance. We also report additional analysis of SARS-CoV-2 human CD4 and CD8 T cell epitope data compiled from these studies, identifying 1,400 different reported SARS-CoV-2 epitopes and revealing discrete immunodominant regions of the virus and epitopes that are more prevalently recognized. This remarkable breadth of epitope repertoire has implications for vaccine design, cross-reactivity, and immune escape by SARS-CoV-2 variants.

在过去的一年里，同行评审和预印本文献中的大量研究报告了冠状病毒 SARS-CoV-2 的病毒学、流行病学和临床特征。迄今为止，已有 25 项研究调查并确定了人类 SARS-CoV-2 衍生的 T 细胞表位。在这里，我们回顾了这些最近的研究、它们是如何进行的以及它们的发现。我们回顾了在整个 SARS-CoV2 蛋白质组中识别的表位如何揭示定义的表位数量与抗原来源大小之间的显着相关性。我们还报告了对从这些研究中汇编的 SARS-CoV-2 人类 CD4 和 CD8 T 细胞表位数据的额外分析，确定了 1,400 个不同的报告 SARS-CoV-2 表位，并揭示了病毒的离散免疫优势区域和更普遍识别的表位。