ABSTRACT

Tetrabutylphosphonium tribromide (TBPTB), a mild and versatile reagent, has been synthesized following an environmentally benign protocol. The new reagent possesses inherent phase transfer properties which facilitates organic reactions in aqueous medium. Thermal stability of the reagent which enables organic reactions under microwave irradiation and recyclability of the spent reagent are special attributes of the new reagent. These properties collectively provide an opportunity for facile, practical, and eco-friendly synthesis of a wide range of pharmaceutically significant and specialty organic compounds such as bromo-organics, isothiocyanates, cyanamides and 2-aminobenzothiazoles in excellent yields on-water under microwave irradiation.

摘要

四溴化四丁基phosph（TBPTB）是一种温和且用途广泛的试剂，已按照环保法规进行了合成。新试剂具有固有的相转移特性，可促进在水性介质中的有机反应。该试剂的热稳定性能使它在微波辐射下发生有机反应，并且废试剂的可回收性是新试剂的特殊属性。这些性质共同为在微波辐射下以优异的产率在水上以优异的产率方便，实用，环保地合成了多种药学上重要且特殊的有机化合物，例如溴有机物，异硫氰酸盐，氰胺和2-氨基苯并噻唑。