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Structures and target RNA preferences of the RNA-binding protein family of IGF2BPs: An overview
Structure ( IF 5.7 ) Pub Date : 2021-05-21 , DOI: 10.1016/j.str.2021.05.001
Sophie Marianne Korn 1 , Corinna Jessica Ulshöfer 2 , Tim Schneider 2 , Andreas Schlundt 1
Affiliation  

Insulin-like growth factor 2 mRNA-binding proteins (IMPs, IGF2BPs) act in mRNA transport and translational control but are oncofetal tumor marker proteins. The IMP protein family represents a number of bona fide multi-domain RNA-binding proteins with up to six RNA-binding domains, resulting in a high complexity of possible modes of interactions with target mRNAs. Their exact mechanism in stability control of oncogenic mRNAs is only partially understood. Our and other laboratories' recent work has significantly pushed the understanding of IMP protein specificities both toward RNA engagement and between each other from NMR and crystal structures serving the basis for systematic biochemical and functional investigations. We here summarize the known structural and biochemical information about IMP RNA-binding domains and their RNA preferences. The article also touches on the respective roles of RNA secondary and protein tertiary structures for specific RNA-protein complexes, including the limited knowledge about IMPs' protein-protein interactions, which are often RNA mediated.



中文翻译:

IGF2BPs RNA 结合蛋白家族的结构和靶 RNA 偏好:概述

胰岛素样生长因子 2 mRNA 结合蛋白(IMPs、IGF2BPs)在 mRNA 转运和翻译控制中起作用,但它们是癌胎儿肿瘤标志物蛋白。IMP 蛋白家族代表了许多真正的具有多达六个 RNA 结合域的多域 RNA 结合蛋白,导致与靶 mRNA 相互作用的可能模式高度复杂。它们在致癌 mRNA 稳定性控制中的确切机制仅部分了解。我们和其他实验室最近的工作极大地推动了对 IMP 蛋白特异性的理解,包括从 NMR 和晶体结构对 RNA 参与和相互之间的了解,为系统的生化和功能研究奠定了基础。我们在这里总结了关于 IMP RNA 结合域及其 RNA 偏好的已知结构和生化信息。文章还谈到了 RNA 二级结构和蛋白质三级结构对特定 RNA-蛋白质复合物的各自作用,包括对 IMP 的蛋白质-蛋白质相互作用的有限知识,

更新日期:2021-05-21
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