The aquatic environment receives a wide variety of contaminants that interact with each other, influencing their mutual toxicity. Therefore, studies of mixtures are needed to fully understand their deleterious effects on aquatic organisms. In the present experiment, we aimed to assess the effects of Cd and Zn mixtures in common carp during a one-week exposure. The used nominal waterborne metal levels were 0.02, 0.05 and 0.10 µM for Cd and 3, 7.5 and 15 µM for Zn. Our results showed on the one hand a fast Cd increase and on the other hand a delayed Zn accumulation. In the mixture scenario an inhibition of Cd accumulation due to Zn was marked in the liver but temporary in the gills. For Zn, the delayed accumulation gives an indication of the efficient homeostasis of this essential metal. Between the different mixtures, a stimulation of Zn accumulation by Cd rather than an inhibition was seen in the highest metal mixtures. However, when compared to an earlier single Zn exposure, a reduced Zn accumulation was observed. Metallothionein gene expression was quickly activated in the analysed tissues suggesting that the organism promptly responded to the stressful situation. Finally, the metal mixture did not alter tissue electrolyte levels.

水生环境接收各种相互影响的污染物，影响它们的相互毒性。因此，需要对混合物进行研究，以充分了解它们对水生生物的有害影响。在本实验中，我们旨在评估 Cd 和 Zn 混合物在鲤鱼暴露一周期间的影响。所使用的标称水性金属水平对于 Cd 为 0.02、0.05 和 0.10 µM，对于 Zn 为 3、7.5 和 15 µM。我们的结果一方面显示了快速的 Cd 增加，另一方面显示了延迟的 Zn 积累。在混合方案中，Zn 对 Cd 积累的抑制在肝脏中显着，但在鳃中是暂时的。对于 Zn，延迟积累表明这种必需金属的有效稳态。在不同的混合物之间，在最高金属混合物中观察到 Cd 对 Zn 积累的刺激而不是抑制。然而，与较早的单次锌暴露相比，观察到锌积累减少。金属硫蛋白基因表达在分析的组织中迅速激活，表明生物体对压力情况迅速做出反应。最后，金属混合物没有改变组织电解质水平。