A strategy to enhance drug effectiveness while minimizing controversial effects consists in exploiting host-guest interactions. Moreover, these phenomena can induce the self-assembly of physical hydrogels as effective tools to treat various pathologies (e.g., chronic wounds or cancer). Here, two Poloxamers®/Pluronics® (P407/F127 and P188/F68) were utilized to synthesize various LEGO-like poly(ether urethane)s (PEUs) to develop a library of tunable and injectable supramolecular hydrogels for drug delivery. Three PEUs were synthesized by chain extending Poloxamer/Pluronic with 1,6-cyclohexanedimethanol or N-Boc serinol. Other two amino-functionalized and highly responsive polymers were obtained thorough Boc-group cleavage. For hydrogel design, the spontaneous self-assembly of the poly(ethylene oxide) domains of PEUs with α-cyclodextrins was exploited to form poly(pseudo)rotaxanes (PPRs). PPR-derived channel-like crystals were characterized by X-Ray powder diffraction, Infra-Red and Proton Nuclear Magnetic Resonance spectroscopies. Cytocompatible hydrogel formulations were designed at PEU concentrations between 1% and 5% w/v and α-cyclodextrin at 10% w/v. Supramolecular gels showed good mechanical performances (storage modulus up to 20 kPa) coupled with marked thixotropic and self-healing properties (mechanical recovery over 80% within 30 s after cyclic rupture) as assessed through rheology. Hydrogels exhibited stability and high responsiveness in watery environment up to 5 days: the release of less stable components as suitable drug carriers was coupled with high swelling (doubling the content of fluids with respect to their dry mass) and shape retention. Curcumin was encapsulated into the hydrogels at high concentration (80 μg ml⁻¹) through its complexation with α-cyclodextrins and delivery tests showed controllable and progressive release profiles up to four days.

提高药物有效性同时最小化有争议的影响的策略包括利用宿主 - 访客相互作用。此外，这些现象可以诱导物理水凝胶的自组装，作为治疗各种病理（例如慢性伤口或癌症）的有效工具。在这里，使用两种 Poloxamers®/Pluronics®（P407/F127 和 P188/F68）合成各种类似乐高的聚（醚氨基甲酸酯）（PEU），以开发用于药物递送的可调和可注射超分子水凝胶库。通过用 1,6-环己烷二甲醇或 N-Boc 丝氨醇扩链泊洛沙姆/普朗尼克合成三个 PEU。其他两种氨基官能化和高响应性聚合物是通过 Boc 基团裂解获得的。对于水凝胶设计，PEU 的聚（环氧乙烷）结构域与 α-环糊精的自发自组装被用来形成聚（伪）轮烷（PPR）。PPR 衍生的通道状晶体通过 X 射线粉末衍射、红外和质子核磁共振光谱进行表征。细胞相容性水凝胶配方设计为 PEU 浓度在 1% 到 5% 之间w / v和 10% w/v 的α-环糊精。通过流变学评估，超分子凝胶显示出良好的机械性能（高达 20 kPa 的储能模量）以及显着的触变性和自愈性能（循环破裂后 30 秒内机械恢复超过 80%）。水凝胶在含水环境中表现出稳定性和高响应性长达 5 天：作为合适药物载体的较不稳定成分的释放与高溶胀性（相对于其干质量的流体含量增加一倍）和形状保持性相结合。姜黄素以高浓度（80 μg ml ^-1) 通过其与 α-环糊精的复合和递送测试显示出长达四天的可控和渐进释放曲线。