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Identifying novel ovarian tumor biomarkers through mining of the transcriptome of circulating immune cells: A proof-of-concept study
American Journal of Reproductive Immunology ( IF 3.6 ) Pub Date : 2021-05-22 , DOI: 10.1111/aji.13469
Shitanshu Uppal 1 , Erin Medlin 1 , Mildred Felder 1 , Arvinder Kapur 1 , Robert C Sterner 1 , Jessica Vazquez 1 , Payton N Lindner 1 , Aleksandar K Stanic 1 , Lisa Barroilhet 1 , Jesus Gonzalez-Bosquet 2 , Manish S Patankar 1
Affiliation  

Treatment of high-grade serous ovarian cancer (HGSOC) will benefit from early detection of cancer. Here, we provide proof-of-concept data supporting the hypothesis that circulating immune cells, because of their early recognition of tumors and the tumor microenvironment, can be considered for biomarker discovery.

中文翻译:

通过挖掘循环免疫细胞的转录组来识别新的卵巢肿瘤生物标志物:概念验证研究

高级别浆液性卵巢癌 (HGSOC) 的治疗将受益于癌症的早期发现。在这里,我们提供了概念验证数据来支持这样的假设,即循环免疫细胞,因为它们对肿瘤和肿瘤微环境的早期识别,可以考虑用于生物标志物的发现。
更新日期:2021-05-22
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