ABSTRACT

Background: Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio are electrocardiographic markers and indices of ventricular arrhythmogenic events. We aimed to investigate ventricular repolarization in normal weight, overweight, obese and morbidly obese individuals by using ECG parameters including the above markers.

Methods: A total of 310 obese patients with various cardiac complaints, who were admitted to our outpatient clinic between May 2020 and January 2021, were prospectively included in the study. Using the World Health Organization (WHO) body mass index (BMI) classification, patients were divided into four groups: normal weight (18.5–24.9 kg/m², n = 48), overweight (25–29.9 kg/m², n = 98), obese (30–39.9 kg/m², n = 119), and morbidly obese (>40 kg/m², n = 45).

Results: The morbidly obese and normal groups were younger in age than the other two groups. The Tp-e interval values for Groups I–IV were 72.1 ± 6.9, 73.1 ± 6.2, 75.7 ± 7.3 and 81.1 ± 6.9, respectively, and significantly different (P < .001). We found that age, BMI, systolic blood pressure (BP) and diastolic BP were independent predictors of a prolonged Tp-e interval.

Conclusions: The principal finding of our study was the gradual increase in Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio starting from the overweight stage and these parameters gradually increase in obese and morbidly obese patients. Additionally, systolic and diastolic blood pressure predicted Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio.

摘要

背景：Tp-e 间期、Tp-e/QT 比值和 Tp-e/QTc 比值是心电图标志物和室性心律失常事件的指标。我们旨在通过使用包括上述标志物在内的心电图参数来研究正常体重、超重、肥胖和病态肥胖个体的心室复极。

方法：本研究前瞻性纳入了 2020 年 5 月至 2021 年 1 月期间在我们门诊就诊的 310 名患有各种心脏疾病的肥胖患者。使用世界卫生组织 (WHO) 体重指数 (BMI) 分类，将患者分为四组：正常体重 (18.5–24.9 kg/m ² , n = 48)、超重 (25–29.9 kg/m ² , n = 98)、肥胖 (30–39.9 kg/m ² , n = 119) 和病态肥胖 (>40 kg/m ² , n = 45)。

结果：病态肥胖组和正常组的年龄均小于其他两组。I-IV 组的 Tp-e 间隔值分别为 72.1 ± 6.9、73.1 ± 6.2、75.7 ± 7.3 和 81.1 ± 6.9，并且差异显着（P < .001）。我们发现年龄、BMI、收缩压 (BP) 和舒张压是 Tp-e 间期延长的独立预测因素。

结论：我们研究的主要发现是从超重阶段开始，Tp-e 间期、Tp-e/QT 比值和 Tp-e/QTc 比值逐渐增加，并且这些参数在肥胖和病态肥胖患者中逐渐增加。此外，收缩压和舒张压可预测 Tp-e 间期、Tp-e/QT 比值和 Tp-e/QTc 比值。