ABSTRACT

Objectives

The current study was designed to examine the therapeutic role of hydroalcoholic extract of Cuscuta reflexa Roxb (CRE) and Peucedanum grande C.B. Clarke (PGE) on letrozole (1 mg/kg) induced polycystic ovary syndrome (PCOS) in female Wistar albino rats.

Methods

PCOS rats were treated with CRE (280 mg/kg), PGE (140 mg/kg) or CRE + PGE p.o. for 3 weeks. Vaginal smears for phase of estrous cycle determination, serum levels of sex androgens, lipid profile, oxidative stress parameters and histopathology of ovarian tissues were investigated.

Results

Diestrous cycle days treated with CRE (group III) or PGE (group IV) decreased significantly (p < 0.05) compared to PCOS control animals (group II). Moreover, weight of uteri in PCOS animals treated with the plant extracts also increased significantly (p < 0.05) compared to that of group II animals. Histopathological examination showed the protective effect of the CRE and PGE indicated by the disappearance of ovarian cyst.

Conclusion

The study demonstrated that the CRE and PGE either alone or in combination hold a significant effect in letrozole induced PCOS rat models and could be useful in the management of reproductive and metabolic disorders related to PCOS.

中文翻译：

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菟丝子和前胡对来曲唑致Wistar大鼠多囊卵巢综合征的改善作用

摘要

目标

目前的研究旨在检查菟丝子(CRE) 和前胡(PGE) 的水醇提取物对来曲唑 (1 mg/kg) 诱导的雌性 Wistar 白化病大鼠多囊卵巢综合征 (PCOS) 的治疗作用。

方法

PCOS 大鼠用 CRE (280 mg/kg)、PGE (140 mg/kg) 或 CRE + PGE po 治疗 3 周。研究了用于确定发情周期阶段的阴道涂片、血清性雄激素水平、脂质谱、氧化应激参数和卵巢组织的组织病理学。

结果

与 PCOS 对照动物（第 II 组）相比，用 CRE（第 III 组）或 PGE（第 IV 组）治疗的绝热周期天数显着减少（p  < 0.05）。 此外，与第II 组动物相比，用植物提取物治疗的 PCOS 动物的子宫重量也显着增加（p < 0.05）。组织病理学检查显示卵巢囊肿消失表明CRE和PGE的保护作用。

结论

该研究表明，单独或联合使用 CRE 和 PGE 在来曲唑诱导的 PCOS 大鼠模型中具有显着效果，可用于治疗与 PCOS 相关的生殖和代谢疾病。