In contrast to extensive studies on bone metastasis in advanced prostate cancer (PCa), liver metastasis has been under-researched so far. In order to decipher molecular and cellular mechanisms underpinning liver metastasis of advanced PCa, we develop a rapid and immune sufficient mouse model for liver metastasis of PCa via orthotopic injection of organoids from PbCre⁺; rb1^f/f;p53^f/f mice.

中文翻译：

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一种新的前列腺癌肝转移小鼠模型揭示了动态的肿瘤免疫细胞通讯

与对晚期前列腺癌 (PCa) 骨转移的广泛研究相比，迄今为止，肝转移的研究尚未充分。为了破译支持晚期 PCa 肝转移的分子和细胞机制，我们通过原位注射 PbCre ^{+ 类}器官，开发了一种快速且免疫充足的 PCa 肝转移小鼠模型；rb1 ^f/f ;p53 ^f/f小鼠。