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Time-dependent changes in placental mRNA expression after delivery due to delayed specimen collection
American Journal of Reproductive Immunology ( IF 3.6 ) Pub Date : 2021-05-20 , DOI: 10.1111/aji.13452
Alexa A Freedman 1, 2 , Britney P Smart 2 , Lauren S Keenan-Devlin 3 , Janedelie Romero 2 , Andrew Franklin 4 , Ann Borders 3, 5, 6 , Linda M Ernst 7 , Gregory E Miller 1, 8
Affiliation  

Current scientific guidelines recommend collecting placental specimens within two hours of delivery for gene expression analysis. However, collecting samples in a narrow time window is a challenge in the dynamic and unpredictable clinical setting, so delays in placental specimen collection are possible. The purpose of our analysis was to investigate temporal changes in placental gene expression by longitudinally sampling placentas over a 24 h period.

中文翻译:

由于延迟标本采集,分娩后胎盘 mRNA 表达的时间依赖性变化

目前的科学指南建议在分娩后两小时内收集胎盘样本以进行基因表达分析。然而,在狭窄的时间窗口内采集样本在动态且不可预测的临床环境中是一项挑战,因此胎盘样本采集的延迟是可能的。我们分析的目的是通过在 24 小时内纵向取样胎盘来研究胎盘基因表达的时间变化。
更新日期:2021-05-20
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