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Small Intestinalization of Colon Using Ileum Organoids
Trends in Cell Biology ( IF 19.0 ) Pub Date : 2021-05-20 , DOI: 10.1016/j.tcb.2021.05.002
Jinjian Huang 1 , Ziyan Xu 1 , Jianan Ren 1
Affiliation  

Given the mismatch in size and morphology of intestinal organoids with native intestine, their application in intestinal segment regeneration has yet to be achieved. By engrafting ileal organoids in epithelium-removed colon, Sugimoto et al. recently constructed transplantable colonic segments with functional ileal epithelium and a subepithelial lymphovascular system, providing hope for the treatment of short bowel syndrome.



中文翻译:

使用回肠类器官的结肠小肠化

鉴于肠道类器官的大小和形态与天然肠道不匹配,它们在肠段再生中的应用尚未实现。通过移植回肠类器官中的上皮去除的结肠,杉本等人最近构建了具有功能性回肠上皮和上皮下淋巴血管系统的可移植结肠段,为短肠综合征的治疗提供了希望。

更新日期:2021-06-10
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