Liquid phase separations are major players in chemical analysis. Liquid chromatography (LC) uses mobile phases that typically contain organic solvents. LC could generate significant volumes of chemical waste especially in routine analysis where many samples are processed. An alternative to LC is capillary electrophoresis (CE) which uses smaller volumes of background solution/mobile phase. In this review, we compared the analytical performance of different modes of LC and CE for the analysis of the same compounds. The modes selected were reversed phase LC versus capillary zone electrophoresis and electrokinetic chromatography, chiral LC versus chiral electrokinetic chromatography, and size exclusion chromatography versus capillary gel electrophoresis. Articles covered were published from 2018 to 2020. We will recommend if CE can replace LC for some applications.

液相分离是化学分析的主要参与者。液相色谱 (LC) 使用通常含有有机溶剂的流动相。LC 可能会产生大量化学废物，尤其是在处理大量样品的常规分析中。LC 的一种替代方法是毛细管电泳 (CE)，它使用较小体积的背景溶液/流动相。在这篇综述中，我们比较了不同模式的 LC 和 CE 对相同化合物的分析性能。选择的模式是反相 LC 与毛细管区带电泳和电动色谱、手性 LC 与手性电动色谱以及尺寸排阻色谱与毛细管凝胶电泳。涵盖的文章发表于 2018 年至 2020 年。