Dry eye disease (DED) is a multifactorial disease affecting approximately 5-50% of individuals in various populations. Contributors to DED include, but are not limited to, lacrimal gland hypofunction, meibomian gland dysfunction (MGD), ocular surface inflammation, and corneal nerve dysfunction. Current DED treatments target some facets of the disease, such as ocular surface inflammation, but not all individuals experience adequate symptom relief. As such, this review focuses on alternative and adjunct approaches that are being explored to target underlying contributors to DED.

中文翻译：

---

干眼病的替代疗法。

干眼病 (DED) 是一种多因素疾病，影响不同人群中约 5-50% 的个体。导致 DED 的因素包括但不限于泪腺功能减退、睑板腺功能障碍 (MGD)、眼表炎症和角膜神经功能障碍。目前的 DED 治疗针对的是该疾病的某些方面，例如眼表炎症，但并非所有患者的症状都能得到充分缓解。因此，本次审查重点关注正在探索的替代方法和辅助方法，以针对 DED 的潜在贡献者。