Pharmacogenetics of tenofovir and emtricitabine penetration into cerebrospinal fluid.,Southern African Journal of Hiv Medicine

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Pharmacogenetics of tenofovir and emtricitabine penetration into cerebrospinal fluid.
Southern African Journal of Hiv Medicine ( IF 1.7 ) Pub Date : 2021-04-28 , DOI: 10.4102/sajhivmed.v22i1.1206
Eric H Decloedt _{1,

2} , Phumla Z Sinxadi ₂ , Lubbe Wiesner ₂ , John A Joska ₃ , David W Haas _{4,

5} , Gary Maartens ₂

Affiliation

Blood-cerebrospinal fluid (CSF) barrier transporters affect the influx and efflux of drugs. The antiretrovirals tenofovir and emtricitabine may be substrates of blood-brain barrier (BBB) and blood-CSF barrier transporters, but data are limited regarding the pharmacogenetics and pharmacokinetics of their central nervous system (CNS) penetration.

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