Cardiovascular magnetic resonance (CMR) myocardial strain analysis using feature tracking (FT) is an increasingly popular method to assess cardiac function. However, different software packages produce different strain values from the same images and there is little guidance regarding which software package would be the best to use. We explored a framework under which different software packages could be compared and used based on their abilities to differentiate disease from health and differentiate disease severity based on outcome. To illustrate this concept, we compared 4-chamber left ventricular (LV) peak longitudinal strain (GLS) analyzed from retrospective electrocardiogram gated cine imaging performed on 1.5 T CMR scanners using three CMR post-processing software packages in their abilities to discriminate a group of 45 patients with heart failure with preserved ejection fraction (HFpEF) from 26 controls without cardiovascular disease and to discriminate disease severity based on outcomes. The three different post-processing software used were SuiteHeart, cvi42, and DRA-Trufistrain. All three software packages were able to distinguish HFpEF patients from controls. 4-chamber peak GLS by SuiteHeart was shown to be a better discriminator of adverse outcomes in HFpEF patients than 4-chamber GLS derived from cvi42 or DRA-Trufistrain. We illustrated a framework to compare feature tracking GLS derived from different post-processing software packages. Publicly available imaging data sets with outcomes would be important to validate the growing number of CMR-FT software packages.

中文翻译：

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通过区分射血分数保留的心力衰竭患者预后的能力比较心血管磁共振应变软件包

使用特征跟踪 (FT) 的心血管磁共振 (CMR) 心肌应变分析是一种越来越流行的评估心脏功能的方法。然而，不同的软件包会从相同的图像中产生不同的应变值，并且几乎没有关于哪个软件包最适合使用的指导。我们探索了一个框架，在该框架下，可以根据不同软件包区分疾病与健康和根据结果区分疾病严重程度的能力进行比较和使用。为了说明这一概念，我们比较了从 1 上执行的回顾性心电图门控电影成像分析的 4 腔左心室 (LV) 峰值纵向应变 (GLS)。5 T CMR 扫描仪使用三个 CMR 后处理软件包，能够将一组 45 名射血分数保留的心力衰竭 (HFpEF) 患者与 26 名没有心血管疾病的对照组区分开来，并根据结果区分疾病的严重程度。使用的三种不同的后处理软件是 SuiteHeart、cvi42 和 DRA-Trufistrain。所有三个软件包都能够将 HFpEF 患者与对照组区分开来。与来自 cvi42 或 DRA-Trufistrain 的 4 室 GLS 相比，SuiteHeart 的 4 室峰值 GLS 被证明是 HFpEF 患者不良结果的更好鉴别器。我们展示了一个框架来比较来自不同后处理软件包的特征跟踪 GLS。