Mesenchymal progenitor cells play a key role in fibrogenesis. An exciting paper was recently published showed that blister fluid from the skin patients with the autoimmune connective tissue disease scleroderma (systemic sclerosis, SSc) preferentially activated mesenchymal progenitor cells (Taki et al. in Arthritis Rheumatol 72(8):1361–1374, 2020). These data provide new and invaluable insights into the complex interactions in the connective tissue microenvironment that ultimately result in persistent, pathological fibrosis.

中文翻译：

---

手指上的水泡

间充质祖细胞在纤维发生中起关键作用。最近发表的一篇激动人心的论文表明，患有自身免疫性结缔组织病硬皮病（系统性硬化症，SSc）的皮肤患者的水疱液优先激活间充质祖细胞（Taki 等人在关节炎风湿病 72(8):1361–1374, 2020 ）。这些数据为结缔组织微环境中复杂的相互作用提供了新的和宝贵的见解，这些相互作用最终导致了持续的病理性纤维化。