当前位置: X-MOL 学术Physiol. Behav. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Effect of combination of peripheral oxytocin and naltrexone at subthreshold doses on food intake, body weight and feeding-related brain gene expression in male rats
Physiology & Behavior ( IF 2.9 ) Pub Date : 2021-05-20 , DOI: 10.1016/j.physbeh.2021.113464
Mitchell A Head 1 , Allen S Levine 2 , David G Christian 1 , Anica Klockars 1 , Pawel K Olszewski 3
Affiliation  

In a recent case report involving a male with hypothalamic obesity, concurrent administration of oxytocin (OT) and an opioid receptor antagonist, naltrexone (NTX), synergistically affected energy balance. Here, by using laboratory rats, we examined whether the reported synergy between OT and NTX in the context of food intake extends beyond that one unique case. We found that intravenous OT+NTX combination, at doses subthreshold for each of the drugs individually, decreased episodic consumption of a 10% sucrose solution in non-deprived animals. Daily administration of OT and NTX just before a scheduled, 2-hour, high-fat high-sugar (HFHS) meal over 24 days, decreased cumulative HFHS diet intake, but without a change in body weight due to compensatory standard chow intake during the remainder of the day. The NTX-OT treatment affected expression of several feeding-related genes in the hypothalamus, brain stem and nucleus accumbens, brain regions essential for the regulation of energy- and reward-driven consumption. We conclude that OT and NTX act synergistically to decrease food consumption in rats and that this transient effect is accompanied by changes in brain processes relevant to feeding.



中文翻译:

亚阈剂量外周催产素与纳曲酮联用对雄性大鼠摄食、体重及摄食相关脑基因表达的影响

在最近的一份涉及下丘脑肥胖男性的病例报告中,同时使用催产素 (OT) 和阿片受体拮抗剂纳曲酮 (NTX) 协同影响能量平衡。在这里,通过使用实验室大鼠,我们检查了所报道的 OT 和 NTX 之​​间在食物摄入方面的协同作用是否超出了这种独特的情况。我们发现静脉内 OT + NTX 组合,在每种药物的单独剂量低于阈值时,减少了非剥夺动物中 10% 蔗糖溶液的偶发消耗。在计划的 2 小时高糖 (HFHS) 餐之前每天服用 OT 和 NTX,可减少 HFHS 饮食的累积摄入量,但由于在此期间补偿性标准食物摄入量,体重没有变化剩下的时间。NTX-OT 治疗影响了下丘脑、脑干和伏隔核中几种进食相关基因的表达,这些区域对调节能量和奖励驱动的消费至关重要。我们得出结论,OT 和 NTX 协同作用以减少大鼠的食物消耗,并且这种瞬时效应伴随着与进食相关的大脑过程的变化。

更新日期:2021-05-28
down
wechat
bug