Exposure to phthalates is widespread and especially early life stages represent a critical window of exposure. In the present study, we investigated the effect of prenatal exposure to phthalates on birth outcomes and weight development in early life. In 130 mother–child pairs, we estimated the association of concentrations of 13 phthalates in spot-urine samples collected during pregnancy and birth outcomes and weight gain in the first two years of life using robust linear regression. High molecular weight phthalates were inversely associated with birth weight in girls but not in boys. Thus, prenatal exposure to phthalates may affect birth weight in a sex-specific manner.

邻苯二甲酸酯的暴露是普遍的，尤其是生命早期阶段是暴露的关键窗口。在本研究中，我们调查了产前接触邻苯二甲酸酯对出生结果和早年体重发展的影响。在 130 对母婴中，我们使用稳健线性回归估计了在怀孕和出生期间收集的现场尿液样本中 13 种邻苯二甲酸盐的浓度与出生后头两年体重增加之间的关联。高分子量邻苯二甲酸盐与女孩的出生体重呈负相关，但与男孩无关。因此，产前接触邻苯二甲酸盐可能会以特定性别的方式影响出生体重。