In chemical industry, major accidents occur occasionally. Past research has demonstrated that risk perception was relevant to safety as it might affect the behavior, which could exert influence on the probability of accidents. It is important to adjust workers' risk perception to reduce accidents in chemical industry. To achieve this goal, some key influencing factors of workers’ risk perception of were identified from 3 aspects including safety attitude, safety knowledge and safety leadership. This was accomplished by gathering empirical data from 287 workers employed in 6 Chemical plants in Jiangsu, China. The model of influencing factors of risk perception for workers was established based on Structural Equation Modelling (SEM), and the path coefficients and weights were analyzed by the SEM. On that basis, the System Dynamics (SD) model of risk perception for workers was established. The study findings revealed safety attitude and safety leadership have a direct positive impact on perception of risk probability and perception of risk severity, safety knowledge has a direct positive impact on perception of risk severity, while safety knowledge has no direct positive impact on perception of risk probability. The findings of the study can provide theoretical supports and method guidance for adjusting the risk perception of workers in chemical industry.