Abstract

Three new lanostane triterpenoids, designated as 6-hydroxyl schiglausin A (1), 29-hydroxyl schiglausin D (2), and 6-hydroxyl schiglausin G (3), were isolated from the ethanol extract of the stems of Schisandra viridis. Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (¹H-¹H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated compounds were tested in vitro for cytotoxic activities. As a result, compound 1 exhibited cytotoxic activities for all six tested human lung cancer cell lines with IC₅₀ values less than 10 μM.

摘要

从绿色五味子茎的乙醇提取物中分离出三种新的羊毛甾烷三萜类化合物，分别命名为 6-羟基西格劳辛 A ( 1 )、29-羟基西格劳辛 D ( 2 ) 和 6-羟基西格劳辛 G ( 3 ) 。除高分辨率质谱外，所有化合物的结构解析均通过光谱方法进行，例如 1D 和 2D ( ¹ H - ^{1 H COSY、HMQC 和 HMBC) NMR 光谱。}在体外测试分离的化合物的细胞毒活性。结果，化合物1对所有六种测试的人肺癌细胞系均表现出细胞毒活性，IC ₅₀值小于 10 μM。